1) What are the host and parasite factors that contribute to the wide spectrum of malaria disease severity?
2) Are there malarial disease characteristics that portend poor clinical outcome? Can they be altered?
3) Is there a distinction between the pathogenetic disease pathways leading to death and those leading to poor outcome? As artemisin based therapies continue to decrease mortality is there a way to decrease morbidity as well? Can we move to ‘saving brains’ in addition to ‘saving lives’?