1) Acute disease
Which key interventions can impact the survival of in-patients admitted with suspected infection in LMIC, specifically Malawi?
2) Chronic disease
Amongst individuals in Malawi with chronic respiratory symptoms (cough, wheeze, disproportion dyspnoea)
a. what is the underlying pathology, and how can this knowledge alter treatment pathways?
b. which treatments can be rational, effective and consistently delivered?
c. What are the costs of living with chronic respiratory diseases which are characterised by intermittent “exacerbations”?
3) Controlled Human Infection Models (CHIM)
How can CHIM in Malawi be used to identify new preventative treatments for respiratory infection (specifically vaccination against Streptococcus pneumoniae)?