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Welcome to MLW

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We conduct internationally excellent research to benefit health and we train the next generation of researchers. In pursuit of this important mission, MLW is implementing two clinical research programmes focusing on preventing death and transmission of infections.

MLW is closely linked with the community and is an integral part of the University of Malawi's College of Medicine. These relationships provide a unique opportunity replicated in few centres in Africa to study major health issues spanning both community and hospital. Malawi provides a unique supportive environment, with government commitment to universal health coverage, strong engagement with research and willingness to innovate around evidence-based public health programmes. MLW surveillance and diagnostic platforms provide clinicians with early indicators of changes in the incidence of common and emerging diseases.

We study individual and community behaviour and bring this together with basic biology in order to plan appropriate interventions that improve health. Our translational pipeline, while providing an excellent academic environment, results in significant clinical trials and we transfer the findings to policy leading to improved health in Malawi and world-wide.

Most Recent Publications

Nasal Pneumococcal Density is Associated with Microaspiration and Heightened Human Alveolar Macrophage Responsiveness to Bacterial Pathogens. Mitsi E, Carniel B, Reiné J, Rylance J, Zaidi S, Soares-Schanoski A, Connor V, Collins AM, Schlitzer A, Nikolaou E, Solórzano C, Pojar S, Hill H, Hyder-Wright AD, Jambo KC, Oggioni MR, De Ste Croix M, Gordon SB, Jochems SP, Ferreira DM. Am J Respir Crit Care Med. 2019 Oct 18

Intensified household contact tracing, prevention and treatment support versus enhanced standard of care for contacts of tuberculosis cases in South Africa: study protocol for a household cluster-randomised trial. MacPherson P, Webb EL, Variava E, Lala SG, Milovanovic M, Ratsela A, Lebina L, Kinghorn A, Martinson NA. BMC Infect Dis. 2019 Oct 12.

Malawian children with uncomplicated and cerebral malaria have decreased activated Vγ9Vδ2 γδ T cells which increase in convalescence. Harawa V, Njie M, Keller T, Kim K, Jaworowski A, Seydel K, Rogerson SJ, Mandala W. PLoS One. 2019 Oct 10

Guidance for Studies Evaluating the Accuracy of Tuberculosis Triage Tests. Nathavitharana RR, Yoon C, Macpherson P, Dowdy DW, Cattamanchi A, Somoskovi A, Broger T, Ottenhoff THM, Arinaminpathy N, Lonnroth K, Reither K, Cobelens F, Gilpin C, Denkinger CM, Schumacher SG. J Infect Dis. 2019 Oct 8

Distinct Biomarker Profiles Distinguish Malawian Children with Malarial and Non-malarial Sepsis. Kortz TB, Nyirenda J, Tembo D, Elfving K, Baltzell K, Bandawe G, Rosenthal PJ, Macfarlane SB, Mandala W, Nyirenda TS. Am J Trop Med Hyg. 2019 Oct 7

Co-trimoxazole or multivitamin multimineral supplement for post-discharge outcomes after severe anaemia in African children: a randomised controlled trial. Maitland K, Olupot-Olupot P, Kiguli S, Chagaluka G, Alaroker F, Opoka RO, Mpoya A, Walsh K, Engoru C, Nteziyaremye J, Mallewa M, Kennedy N, Nakuya M, Namayanja C, Kayaga J, Nabawanuka E, Sennyondo T, Aromut D, Kumwenda F, Musika CW, Thomason MJ, Bates I, von Hensbroek MB, Evans JA, Uyoga S, Williams TN, Frost G, George EC, Gibb DM, Walker AS; TRACT trial group. Lancet Glob Health. 2019 Oct;7